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KMID : 1161420210240060626
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Journal of Medicinal Food
2021 Volume.24 No. 6 p.626 ~ p.634
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Myrciaria dubia Juice (camu-camu) Exhibits Analgesic and Antiedematogenic Activities in Mice
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da Silva Francisco Carlos
de Souza Alessandra Hubner
Bassoli Bruna Kempfer
Prates Gleiciane Alves
Daudt Cintia
de Oliveira Meneguetti Dionatas Ulises
Correa Aurea Pandolfo
de Oliveira Iasmine Berbigier
de Vargas Schons Sandro
Fialho Maria Fernanda Pessano
Correa Dione Silva
Picada Jaqueline Nascimento
de Barros Falcao Ferraz Alexandre
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Abstract
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The Myrciaria dubia (Myrtaceae) fruit is traditionally used to treat malnutrition due to its high levels of vitamin C and phenolic compounds. Because of its composition, this plant is very promising in the research of novel natural treatment for pain disorders. This study analyzed the phytochemical profile of M. dubia juice and assessed its antinociceptive and antiedematogenic potential. The phytochemical profile was determined through high-performance liquid chromatography (HPLC), the oral antinociceptive effect of M. dubia 50% juice (Md50) was evaluated by formalin, hot plate and Complete Freund's Adjuvant tests and the antiedematogenic activity by paw edema. HPLC revealed the presence of ascorbic acid, rutin, and ellagic acid as major compounds. Md50 showed an antinociceptive effect in the acute and chronic phases of the formalin test. In the hot plate test, Md50 also induced an antinociceptive effect of 0.5 up to 6?h, showing antinociceptive and antiedematogenic potential without changing the spontaneous locomotion of animals. All protocols were submitted and approved by the Ethics Committee for use of Animals of the Lutheran University of Brazil (protocol No. 2013-30P).
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KEYWORD
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CFA, formalin, hot plate, inflammation, pain
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